HI Bruce,
The desktop colour approach is the most direct way of distinguishing between companies. The status line in a module displays the company name from the company profile (or as much of it as will fit). If you hover the cursor over the company name, Adagio shows the directory and data extension on the leftmost panel of the status line.
Me - I'd do both - change the desktop colour and make sure that the company names are unique and distinctive in their early characters.
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Andrew Bates