Hi, Bruce,
Generally speaking, mapped drives are still used. For applications having release dates of March 2011 and more recent, if installing from Win7 and UAC is enabled, you need to use the UNC for the install; otherwise, you'd have to set UAC to Never. If you're setting up a scheduled task for DataCare on a server, then you need to use UNC's everywhere, even the ADSPROF. The RTD should be the same drive as the Softrak folder. There may be some browsers where the drive letter is still required.
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Regards,
Softrak Tech Support