I did a search on +Trend +Micro on this forum and found a couple of hits.

Here is one.

We don't have a known reason for this, and have only heard of this a couple of times. Check the other hits on this website for the above search and there are successful usages of Trend Micro with Adagio (including Adagio consultants who use it in house). There may be an AV settings that is doing this.