There are so many questions that could be asked here...

Is this an installation that has been running well for many months and has suddenly started giving trouble ? or is this a recent Adagio installation on the TS ?

There are different ways of implementing Adagio in a TS environment with respect to what Server (physical PC) is the Domain Controller, the File Server, the TS. They could be all different boxes, they could (but shouldn't) be all the same box or somewhere in between. How are you set up ?

As Andrew asked, what are the other apps that are running on the TS ? Are they database intensive apps like Adagio ? Are they setup the same way with respect to where the programs and data are located ?

Of course it might be solved on the forum, but to be honest, I believe that this is the type of issue best handled by a more direct interaction with your Adagio Consultant working in tandem with your TS guru to t/shoot the issue.

Good luck...

Pete